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Repage (Repaglinide)
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Repaglinide

Repage is a short-acting insulin secretagogue with high interindividual variability in pharmacokinetics due to genetic polymorphisms. We report the first case of Repage-induced factitious hypoglycemia in a young male. It is at least as effective in reducing HbA1c and fasting plasma glucose as sulphonylureas, metformin, or the glitazones and in combination therapy with other drugs, Repage is as effective as any other combination.

Other names for this medication:
Repaglinide, Prandin, Glimet, Novonorm, Premil, Regan, Repaglinida, Eurepa, Repage, Page, Repa,

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Repage is used to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Repage helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose by stimulating the pancreas to release insulin.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems.Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

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Radiation-induced mitotic delay: duration, dose and cell position dependence in the crypts of the small intestine in the mouse. pneumoniae was reproducible and predictive of a significant positive culture.

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These results define further the nature of the constraints on the interaction between Mph FcRI and particular IgGs. Previous work in this laboratory has suggested that antagonist action of 5-hydroxytryptamine2 (5-HT2) receptors and agonist action of 5-HT1 receptors results in antidepressant-like effects (increased reinforcement rate and decreased response rate) in rats performing under the differential-reinforcement-of-low-rate 72-sec schedule (DRL 72-s) of reinforcement.

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Band compressions were particularly well resolved, and reading length was optimal when a ratio of 7-deaza-dGTP:dITP of 4:1 was used in the in vitro DNA synthesis with AmpliTaq FS DNA polymerase. Baseline serum was analysed for myeloperoxidase and lactoferrin. To identify novel mutations in FZD4 gene that cause familial exudative vitreoretinopathy (FEVR) in Indian patients. Progress is being made on elucidating how chromatin alterations, and how proteins catalyzing these alterations, mechanistically contribute to tissue-specific tumorigenesis. Previous results comparing a double-phase technique with single-proton emission computed tomography (SPECT) or with subtraction techniques demonstrated a high detection rate, especially when SPECT and subtraction techniques were used, whereas the double-phase protocol revealed only moderate results.

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The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data. Nitrogen addition decreased C:N ratios, but this response was greater in the ambient CO(2) treatments than under elevated CO(2). We employed invasion, migration and gelatin zymography assays to characterize the effect of metformin on HT-1080 cells. The IGF binding site has been shown to comprise residues in both the aminoterminal and carboxyterminal domains. The results demonstrated differential effects of mineral deletion on tissue mineral content depending on both mineral assessed and source of the mineral.

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Passive Transcutaneous Bone Conduction Hearing Implants: A Systematic Review. A phase II study of mitozantrone in advanced carcinoma of the ovary. Resistance to antibiotics of mycobacteria of the Province of Cadiz Using multiviewpoint images for multiuser interaction does not require special hardware and scales transparently with the number of colocated users in a system. Incidence of deep venous thrombosis of the lower extremities in patients subjected to abdominal surgery

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Bacterial transcriptome remodeling during sequential co-culture with a marine dinoflagellate and diatom. Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis. A clearer understanding of the role of descending systems in motor control can be achieved by using in vitro preparations of mammalian spinal cord that display patterned motor output, together with the use of selective pharmacological agents. The possible link with Churg-Strauss syndrome requires further investigation. The occurrence of oxidase-positive non-gonococcal strains on Thayer-Martin selective media used in the laboratory diagnostic of N.

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Five different columns traditionally employed for the separation of proteins were used, and results were compared with those obtained when using different sub-2 microm particle columns. However, FcgammaR-deficient NKT cells were functionally intact in terms of TCR-induced activation.

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A study of some fast-growing scotochromogenic mycobacteria including species descriptions of Mycobacterium gilvum (new species) and Mycobacterium duv alii (new species). Here, we propose a novel framework for unsupervised characterization of flow patterns through nonlinear manifold learning. Predicting the biologic behavior of melanocytic neoplasms (benign versus malignant) based on histology is one of the most difficult challenges in surgical pathology and dermatology. Excellent localisation in the metastases of the I131 labeled antibodies was demonstrated by SPECT and the treatment was well tolerated. Economic impact of preoperative intraaortic balloon pump therapy in high-risk coronary patients.

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Early and continued assessment of diabetes risk, as part of patient care, will help identify individuals most likely to develop diabetes and allow for early interventions to reduce risk factors as well as delay or may even prevent disease onset. Antimicrobial peptides are predominantly small cationic polypeptides that are classified together on the basis of these molecules to directly kill or inhibit the growth of microorganisms including mycobacteria, and to activate mechanisms of cellular and adaptive immunity. The purpose of this study is to elucidate the molecular mechanism of one-way serological reaction between XJ-160 virus and SINV by recombinant viruses which exchanged the glycoprotein genes individually or simultaneously. Cell-cycle flow-cytometric analysis showed that a substantial fraction of HL60 cells accumulated at the G0/G1 transition.

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Mps1 has emerged as a potential target for cancer therapy, and a variety of compounds have been developed to inhibit its kinase activity. The clinical characteristics of violence profiles indicate that cocaine use, PTSD symptoms, and legal involvement are treatment needs that vary with violence profile and may be useful for clinical decision making.

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Depot leuprolide (3.75 mg/month) or saline was administered intramuscularly for three consecutive treatment cycles. Because purinergic receptors are known mediators of sensory afferent excitation, inhibition of efferent ATP release by BoNT/A could also help to ameliorate acute pain and urgency sensation reported by some recipients. Adjuvant cisplatin-based chemotherapy is recommended for routine use in patients with Stage IIA, IIB or IIIA non-small cell lung cancer (NSCLC) after complete resection.

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Predicting the presence of sleep-disordered breathing in children with Down syndrome. To determine the factors that are related to short-term survival and to develop a model that can be used to estimate prognosis in terminal lung cancer patients. This acute in-vivo study sought to provide insights regarding the feasibility of performing complex bifurcation stenting with Magmaris magnesium-alloy bioresorbable scaffolds (Biotronik,Bulach, Switzerland). Using the cDNA clone pE7, which encodes 2.4 kilobases of the human EGF receptor mRNA, as a hybridization probe, we have found that exposure of MDA-468 cells to EGF results in elevated levels of EGF receptor mRNA.

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Irritant symptoms were associated with TP and BSP concentrations at or below 0.5 mg/m(3). Three-dimensional contrast enhanced ultrasound (3D CEUS) is a novel imaging technique that may be more sensitive to blood flow detection than CTA or 2D CEUS. A cohort study of the prevalence and impact of comorbid medical conditions in pediatric bipolar disorder. The general applicability of this method is shown for three Hyp-containing peptides as well as collagen type I. However, the molecular mechanism of their regulation and function as well as the significance of other ncRNAs such as small nucleolar RNAs during atherogenesis is largely unknown.

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In vitro translation of total cellular RNA, extracted from the lungs of pregnant rabbits at various days throughout gestation, and immunoprecipitation of newly synthesized P-450PG-omega demonstrated a similar gestational age-dependent increase in translatable P-450PG-omega mRNA, as was observed with omega-hydroxylase activity and P-450PG-omega protein levels. Mean duration of the hyperventilation-induced SREDA was approximately three times longer than spontaneous events. Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies. Operative strategies to reduce cerebral embolic events during on- and off-pump coronary artery bypass surgery: A stratified, prospective randomized trial.

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Glycogen synthase kinase 3 (GSK-3) is involved in the regulation of several physiological processes, including glycogen metabolism, protein synthesis, transcription factor activity, and developmental control. Genotypes were determined by PCR-RFLP methods in a study population of African descent consisting of 266 PCa patients and 196 male controls. Although the morphological diversity is remarkable, the endemic cyprinid taxa in East Asia emerged as a monophyletic clade referred to as Xenocypridini. The comparative approach has wide-spread potential to reinvigorate tests of classic hypotheses about the evolution of interspecific interactions. Interactions among different classes of compounds, frequently with opposing effects, complicate hazard evaluation and risk assessment.

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By means of the proposed method it is possible to increase the reliability of the flame photometric determination of potassium and sodium in water analysis. Neighbor Affinity-Based Core-Attachment Method to Detect Protein Complexes in Dynamic PPI Networks. BALB/c mice were infected with strains 2308 and PHE1 to assess the effect of the htrA mutation on virulence, and significantly fewer brucellae were recovered from the spleens of mice infected with PHE1 than from those of mice infected with 2308 at 1 week postinfection. Bone marrow transplantation for the treatment of X-linked adrenoleukodystrophy.

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In this review, we focus on the GC-independent pathway of memory B-cell development, and discuss how the unique features of memory B cells are maintained in the GC-independent pathway. Regenerative reinnervation by thin nociceptive and sudomotor fibers was higher than by large sensory and alphamotor fibers in all groups.

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The present study further investigated whether modulation of TRPC3 is involved in H-R-induced KCa channel inhibition and associated vasodilatory dysfunction using approaches of wire myography, whole-cell voltage-clamp, and coimmunoprecipitation. This study used data from a survey of 2,919 New Zealand secondary school students who participated in the 2014 national Youth In-depth Survey. Participation in the X-PERT Programme by adults with Type 2 diabetes was shown at 14 months to have led to improved glycaemic control, reduced total cholesterol level, body weight, BMI and waist circumference, reduced requirement for diabetes medication, increased consumption of fruit and vegetables, enjoyment of food, knowledge of diabetes, self-empowerment, self-management skills and treatment satisfaction. Further investigations, however, suggest that this disappearance is secondary to T cell-APC interactions, also known as T cell conditioning, and disruption of these putative interactions during splenic processing improves recovery of Ag-specific memory CD8 T cell populations after immunization.

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Low serum insulin-like growth factor 1 (IGF-1): a significant association with prostate cancer. It presents the updated classifications for tooth surface lesions termed dental wear, and discusses the wear behavior of various restorative materials. Other growth factors, fibroblast growth factor of 10 ng/ml and insulin of 25 mumol/ml had no effect on actin distribution. Provision of postnatal care to non-western clients may require special skills and measures. Tricetin is a flavonoid derivative and a potent anti-inflammatory and anticancer agent.

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Experiments with mitochondria isolated from the neocortex and hippocampus showed that state 3 respiratory rates decreased during ischemia, recovered after 1 and 3 h of recirculation, and then showed a secondary decline at 6 h. The aim of this paper is to investigate the association between established determinants of birth weight and these separate components. These findings have vital implications for health outcomes and resource planning. In another type, the originally intended hypothesis for testing may be modified using the internal data accumulated at an interim time of the trial, such as changing the primary endpoint vivamus somnia vestra meaning of names and dropping a treatment arm. Integrative functional analyses using rainbow trout selected for tolerance to plant diets reveal nutrigenomic signatures for soy utilization without the concurrence of enteritis.

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