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Topictal (Topiramate)
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Topiramate

Topictal is the brand name of Topictal, an anticonvulsant drug used to prevent seizures and reduce the frequency of migraines. While its exact mechanism of action is unknown, studies suggest Topictal might alter the production or action of neurotransmitters in the brain, suppressing the abnormal activity of the nerves in the brain that cause seizures or preventing the abnormal activity from spreading to other nerves. Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. The Food and Drug Administration (FDA) approved Topictal to treat seizures in 1996.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topictal comes as a tablet, a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food), and an extended-release (long-acting) capsule to take by mouth. The tablets and sprinkle capsules are usually taken with or without food once or twice a day. The extended-release capsules are usually taken with or without food once a day. Take Topictal at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Topictal exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

There is another medication with a name similar to the brand name for Topictal. You should be sure that you receive Topictal and not the similar medication each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given Topictal. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Topictal tablets have a bitter taste so you should swallow them whole. It is especially important that you not take Topictal tablets that have been broken for any length of time because tablets that are broken may lose their effectiveness over time.

The sprinkle and extended-release capsules (Qudexy XR brand only) may be swallowed whole or opened and poured over soft food. Swallow extended-release capsules (Trokendi XR brand only) whole; do not split, chew, or sprinkle on food.

To take the sprinkle capsules or extended-release capsules (Qudexy XR brand only) with food, follow these steps:

  1. Prepare a teaspoonful of soft food such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.
  2. Hold the capsule upright over the food.
  3. Twist off the top of the capsule and pour the entire contents onto the spoonful of food.
  4. Swallow the entire mixture immediately without chewing.
  5. Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.

Your doctor will probably start you on a low dose of Topictal and gradually increase your dose, not more than once every week.

Topictal may control your seizures or migraines but will not cure your condition. Continue to take Topictal even if you feel well. Do not stop taking Topictal without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking Topictal, you may have severe seizures, even if you have not had seizures in the past. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Topictal and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

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Immunologic reorganization of persons vaccinated cutaneously with vaccinal strains of Br. Maintaining ongoing education and feedback on the use of the document were highlighted as important mechanisms for ensuring that the delivery of care remained optimum. Worldwide there is a large variation in outcome (death, myocardial infarction and recurrent myocardial infarction) in patients with unstable angina or non-Q wave myocardial infarction. Two-dimensional transferred nuclear Overhauser effect spectroscopy (TRNOESY) studies of nucleotide conformations in arginine kinase complexes.

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ROM cut-off values of each joint for the absence of disability in each HAQ-DI category were determined using ROC curves. thin film technologies and dye-sensitized solar cells (DSCs) help to replace the use of silicon, which is expensive. In conclusion, we suggested that Ras overexpression leads to cell proliferation through activating Ras/PI3K/GSK3beta/EP(4) PGE(2) receptor signals and caused a feedback regulation of Ras by EP4 in colorectal tumor progression. Individual variation in growth hormone gene expression was observed between fetuses at day 19 of gestation (6 out of 8 fetuses examined were positive for growth hormone mRNA). Recurrent squamous cell carcinoma arising in a neglected pilonidal sinus: report of a case and literature review.

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To investigate the hypothesis that synovial fluid (SF) from patients with osteoarthritis (OA) may contain calcium phosphate crystals that are either too small, or too few in number to be identified by conventional light microscopy techniques. Sensor proteins detect various forms of damage, and convey signals via a complex pathway regulated by protein phosphorylation, stabilization and transcriptional regulation.

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Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. These findings indicate that circadian clock gene expression variations in BM are developmentally regulated.

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Voltage-sensitive calcium flux into bovine chromaffin cells occurs through dihydropyridine-sensitive and dihydropyridine- and omega-conotoxin-insensitive pathways. The results indicate that the ARBQ has good psychometric characteristics, supporting the feasibility of its use in measuring abuse-related beliefs in research on survivors of CSA. To our knowledge, this is one of the first reports of lipoatrophy with Aspart, biphasic Aspart and Detemir insulin analogues (Novo Nordisk, Bagsvaerd, Denmark).

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Rapid detection of Australia antigen by counterimmunoelectrophoresis. Multivariate logistic regression analyses were used to develop models predicting rheumatology fellowship. The day after taking the drug, the mean concentration of chloroquine and desethylchloroquine in whole blood were 1305 nmol/l and 915 nmol/l, respectively, and immediately before the next weekly dose, 489 nmol/l and 384 nmol/l, respectively. This network is a distillation of the knowledge from all previous publications on the Snf1/AMPK pathway.

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Its analgesic effects are also documented for diabetic neuropathic pain, but they are limited because it is administered as a single-dose. Anti-inflammatory and antioxidative effects of telmisartan that were exerted in part by peroxisome proliferator-activated receptor-gamma activation, but not its blood pressure-lowering effect, have protective roles against cognitive impairment and white matter damage after chronic cerebral hypoperfusion. They find that despite a steady accumulation of positive findings over the past decade, the precise role of sleep in memory and brain plasticity remains elusive. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable.

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Effect of Mesenchymal Stromal Cells on T Cells in a Septic Context: Immunosuppression or Immunostimulation? A strong correlation between severity of ataxia and linguistic performance was consistently found.

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To circumvent this problem, an indirect labelling strategy was developed based on the substitution of the fluorophore with allele-specific 22 bp universal labelling sequences (ULS). Effect of polyalkyl polyphosphonates on bone development in young rats. We measured airflow, volume (pneumotachograph), esophageal pressure (nasogastric-esophageal balloon), and airway pressure (airway catheter) in 10 patients intubated with no.

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SCOPA-Sleep is a feasible, consistent, and useful scale for assessment of sleep disorder in PD patients. Intensive chemotherapy with autologous peripheral-blood stem-cell rescue in metastatic breast cancer. Purification, antibody activity and ultrastructure of secretory and high-polymer IgA. Albumin alone could direct nanoparticle uptake by human macrophages, which involved class A but not class B scavenger receptors. However, this study shows that they can negatively affect the environment if their by-products are not appropriately utilized as intended.

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In this regard, we examined the influence of hypoglycemic fungal polysaccharides (EPS) on the time-dependent plasma protein alterations in streptozotocin-induced diabetic rats. The study was conducted at the University of Maryland at College Park and at Baltimore, and the University of Pittsburgh General Clinical Research Center.

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To evaluate the effect of gluten free diet (GFD) on magnetic resonance spectroscopy (MRS) of the cerebellum in patients with gluten ataxia (GA). Response models based on artificial neural network (ANN) and partial least squares (PLS1) were built, tested and compared for the simultaneous determination of urea, ammonium, potassium and sodium.

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These regions harbor distant regulatory elements, enhancers, super-enhancers, insulators, alternative promoters, and sequences that transcribe as noncoding RNAs (ncRNAs) such as miRNAs and long ncRNAs. Using ACC patches we show that dermal exposure to benzene and toluene in a shoe manufacturing factory is probably rare, and when it occurred exposures were relatively low and did not significantly contribute to systemic exposure. The major metabolic pathways in mammals are conjugation with activated sulfate and glucuronic acid, while a small amount of acetaminophen forms a chemically reactive and highly toxic, hydroxylated metabolite. These data indicate that although the titer of Hageman factor strongly influences the cold activation of factor VII, other factors may affect these phenomena.

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To report the acute management and clinical findings of a case of corneal bee sting and to report the outcome of corneal endothelial cell analysis 1 year after trauma. Most importantly, the data demonstrate that the liver is one of the major organs for the production of soluble CD14. This increases bile acid synthesis and consequently reduces serum low-density lipoprotein cholesterol.

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This is an ancillary analysis of 1381 patients from the PAULA study, which was a cross-sectional, retrospective and nationwide multicenter study. Children with new-onset epilepsy: neuropsychological status and brain structure. A systemic review of published medical literature that compares and contrasts different classes of sclerosants is presented. Tissue heterogeneity results in a systematic error which lowers the derived flow values. Many complications can be seen after organ transplants on short and long term as rejection, vascular compromise, and infection.

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Impact of lifestyle factors and nutrients intake on occurrence of gastrointestinal cancer in Tunisian population. The major complication rate associated with this technology is low in the context of similar reports of conventional radiofrequency catheters.

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Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis. Similarly, the antimigraine efficacy of LY466195 seems unrelated to vascular CGRP-mediated pathways and/or receptors. To our knowledge, this is the first report on a prophylactic cross-face nerve flap technique for the protection of facial muscles before facial nerve transection, and also the usefulness of vascularised lateral femoral cutaneous nerve flap. Comparative genomic hybridization (CGH) analysis revealed gains of 11(q13 approximately q14) and 12(q11 approximately q21), loss of 11(q21 approximately qter), and 2 amplicons at 12(q12 approximately q13) and 12(q14 approximately q21).

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Is there a correlation between brain naturietic peptide levels and echocardiographic and hemodynamic parameters in heart transplant patients? Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment. This study shows that Drosophila KDM4A (dKDM4A), previously characterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator, predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation (PEV), organization of repetitive DNAs, and DNA repair. The morphologies of BALB/c and 129 W9.5 EBs were very similar at day 4, whereas C57BL/6 EBs were distinct from the others at day 4. Three overlapping peptides containing linear B-cell epitopes and corresponding to the consensus sequence of hypervariable region 1 (HVR1) from protein E2 were studied for their capacity to interact with the sera from patients with acute and chronic hepatitis C.

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Headaches of patients in the experimental and control groups at 24, 48, and 72 hours after the operation were determined. Among all experimental groups, the combination of culture medium conditioned by heat shocked hFOB cells together with chemical stimuli, exhibited the highest level of calcium mineralization, as assessed by Von Kossa staining. The TLC method described can be used to set up similar low-cost, drug quality screening laboratories in other developing countries where analytical chemistry expertise is lacking, resources are scarce, and sophisticated analytical laboratories to assess drug quality are not available.

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Patient characteristics and outcomes of endovascular AAA repair (EVAR) of EUROSTAR and DREAM-trial participants were compared. Suprachiasmatic nuclei (SCN) contain a circadian oscillator that is normally synchronized by the light/dark cycle.

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The versatility of the selection process lends itself to efficient screening methodologies and can increase the number of antigen binding clones that can be isolated. difficile 630 for transposon mutagenesis a erythromycin-sensitive derivative C. The initiation and maintenance of cellular differentiation for a variety of cell types has been shown to be influenced by the microenvironment.

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The subjects of the study were 65 children from 0 to 5 years of age and their mothers. The mechanisms that drive anti-nociceptive tolerance, however, are less well understood.

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Acute kidney injury (AKI) is a common critical syndrome, with high morbidity and mortality. We suggest that there is a role for ongoing immunosuppressive therapy in these patients. Degradation of polyhydroxyalkanoates and the composition of microbial destructors under natural conditions

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The aim of this study was to contrast the effects of using chronological age and those of using corrected age on measures of cognitive outcome across childhood. Fatal occupational injuries in the Arkhangelsk region, Northwest Russia. Meconium microbiome analysis identifies bacteria correlated with premature birth.

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In this xenograft model, Z-360 significantly reduced the tumor weight, increased TUNEL-positive cells and suppressed the expression of anti-apoptosis factors such as survivin, XIAP and Mcl-1, and these effects of Z-360 combined with gemcitabine were more effective. Clinical and EEG response to anticonvulsants in neonatal seizures. Unlike a group of infants without identifiable disabilities, those with Down syndrome did not learn the contingency. Developmental Work Research (DWR) is the framework against which data from the work practice and system development where analyzed and interpreted.

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A convenient method for the synthesis of DNA-recognizing polyamides in solution. Effects of recombinant human interferon alpha (HuIFN-alpha) on human megakaryocyte (CFU-MK) and fibroblast (CFU-F) colony-forming cell growth were studied. Intracranial meningioma at the site of a previous cranial penetrating trauma due to shrapnel.

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The latter might share characteristics with a scanning SRP complex, whereas the former represents the next step: the targeting complex ready for receptor binding. Residue analyses of the active ingredient, azadirachtin, determined that it had a half-life of 36 to 48 h in water exposed to natural sunlight. Possible mechanisms of the protective action of alkylhydroxybenzenes in relation to DNA are discussed, namely, the prevention of its hydrolysis due to isolation from the aqueous environment and maintaining DNA stability in the dormant forms of microorganisms.

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QST monitored somatosensory deficits and recovery of inferior alveolar nerve functions in all patients. In contrast to the effects of placebo, GH secretion increased distinctly and rapid-eye-movement (REM) density decreased during the second half of night. Spiritual practices may help in the management of physical pain. These results indicate that rhythmic variation of NE in the SCN is driven by an endogenous pacemaker and independent of external light. Action of a diffusible target-derived chemoattractant on cortical axon branch induction and directed growth.

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The serological analysis of recombinant cDNA expression libraries (SEREX) were previously modified using a severe combined immunodeficient (SCID) mice model engrafted with fresh human lung cancer. Multivariable regression models were used to estimate effects of psychosocial variables adjusted for potential confounders.

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Estimation of a nationwide statistics of hernia operation applying data mining technique to the National Health Insurance Database Differences in values of linkage disequilibrium between women with repeated abortions and those of normal fertility were not found. Altered median nerve deformation and transverse displacement during wrist movement in patients with carpal tunnel syndrome.

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They were mainly used for indigestion, chronic diarrhea, common cold, blood pressure, blood sugar. Spectrum of pathogens in native liver, bile, and blood during pediatric liver transplantation. Pharmacokinetics of cefpodoxime proxetil in healthy young and elderly volunteers. Over the past decade, studies involving short-term hypoxic exposure have greatly advanced our knowledge regarding underlying mechanisms and predisposing events of hypoxic pulmonary hypertension. Embryological origins and clinical considerations including median nerve entrapment are considered.

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Excision of the anomalous muscle and release of the clavicular part of the sternocleidomastoid muscle abolished the complaints. This rather negative perception of health could be a result of actual illness or a result of more concern about illness.

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The inhibitory effect of Ras N-17 was overcome by simultaneous injection of a plasmid expressing an active raf oncogene, indicating that it resulted from interference with the Ras/Raf signaling pathway. Files were systematically searched for all cases of central (intraosseous) odontogenic tumors during a 20-year period.

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The effect of policosanol (5 and 10 mg day(-1) on LDL-C oxidation was studied in a double-blind, randomized, placebo-controlled trial conducted in 69 subjects. For each species, the time course of growth and viability during mixed culture cultivations was obtained by using qT-RFLP analysis in combination with flow cytometry. Extensive research has been conducted on the subject of cultural influences on behaviors, attitudes, beliefs and interpersonal relations of patients in the medical world.

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Orofacial manifestations of a group of British patients infected with HIV-1. We report a case of ureteral injury with acute-onset uro-retroperitoneum in a volunteer oocyte donor. The most striking observation drawn from these data is certainly the close resemblance, at all latencies, between evoked responses elicited by electrical stimulation and those elicited by acoustic stimulation. With the exception of one child who was admitted overnight for a low-grade fever, all were released from hospital within a few hours.

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Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: role of tissue hypoxia. Molecular analysis and chromosomal assignment of the canine CALC-I/alpha-CGRP gene. The subsequent results indicated that, briefly, the PEG molar ratio did negligible influence on the size distribution of NPs, however, it did have great effect on the NPs zeta potential and hydrophilicity as well as the Hb loading amount. The enzyme can use phosphatidylinositol (PtdIns), PtdIns 4-phosphate and PtdIns (4,5)-bisphosphate as substrates in vitro, but it seems to phosphorylate PtdIns (4,5)-bisphosphate preferentially in vivo. Preparation and characterization of porous PDLLA/HA composite foams by supercritical carbon dioxide technology.

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Only those patients with no evidence of osteonecrosis on preoperative magnetic resonance imaging who later had development of osteonecrosis and subsequently required a knee arthroplasty were included. IGF binding proteins (IGFBPs) are a family of structurally homologous proteins that bind IGFs with high affinities and can modulate IGF activity. The contaminants were analyzed by various techniques mainly by total reflection x-ray fluorescence. Capabilities of and limitations to microsurgical procedures are presented in selected cases.

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One hundred patients aged bcs classification of esomeprazole side 43 to 81 were classified into four types (types 1 to 4) according to the degree of chest X-ray findings. mansoni tetraspanin antigen, SmTSP-2, within the large extracellular domain. To assess the sensitivity and specificity of computed tomography (CT) in the diagnosis of aortoenteric fistula (AEF) and to determine the most accurate CT signs of the disease. To examine the efficacy of adjunctive ziprasidone for cognitive symptoms in adult patients with major depressive disorder (MDD) experiencing persistent symptoms after 8 weeks of open-label escitalopram.

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Maternal and child health indicators in Belo Horizonte, Minas Gerais State, Brazil, 2001: an analysis of intra-urban differences The short hairpin RNA-mediated inhibition of ESR1 in SCC- and precancer-derived cell lines increased invasiveness in both in vivo and in vitro assays. The progress of utilizing these green solvents in polymerization processes is reviewed and discussed in this critical levoxin tablet for kids review on the basis of results mainly published during the last five years (216 references). Double leptospira-carrying in a single individual of Micromys minutus. Thus, behavioral deficits were observed only in rats with a lesion to the infracallosal component of the septohippocampal pathways, the behavior of rats with the combined lesions being similar to that of rats with single lesions of the infracallosal pathways in most measures.

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